Combined effects of methyl n-butyl ketone and methyl ethyl ketone on activities of microsomal drug metabolizing enzymes in rats.

Methyl ethyl ketone and methyl isobutyl ketone not carcinogenic.

Methyl Ethyl Ketone and Methyl Isobutyl Ketone Not Carcinogenic The April 22, 1993, issue of Environmental Health Perspectives contained a commentary by Legator and Strawn entitled "Public Health Policies Regarding Hazardous Waste Sites and Cigarette Smoking: An Argument by Analogy." Although the article does not include any discussion of either methyl ethyl ketone (MEK) or methyl isobutyl keto...

Methyl ethyl ketone peroxide

Thermal Hazard Analysis of Methyl Ethyl Ketone Peroxide

In the past forty years in Japan and Taiwan, many thermal explosions have been caused by methyl ethyl ketone peroxide (MEKPO) under the influence of external fire and others. Thermograms of commercialized MEKPO dimers were first screened by Differential Scanning Calorimetry (DSC) to determine the heat of decomposition and exothermic onset temperature. Thermal runaway phenomena were then thoroug...

[An organic peroxide, methyl ethyl ketone peroxide, damage to cytochrome P-450 peroxidase and microsomal enzymes activity].

In vivo, an organic peroxide, methyl ethyl ketone peroxide (MEKP) damaged microsomal cytochrome P-450 and cytochrome P-450 peroxidase in vitamin E deficient rat livers. Dietary vitamin E protected the microsomal enzymes from MEKP damage. Phenobarbital induced liver cytochrome P-450 peroxidase and glutation S-transferase and decreased MEKP damage on microsomal enzymes. MEKP induced production of...

Effects of ethanol on the kinetics of methyl ethyl ketone in man.

The kinetics of inhaled methyl ethyl ketone (MEK) at a concentration of 200 ppm for four hours were studied in volunteers after swallowing ethanol at a dose of 0.8 g/kg. Ethanol was given either before or at the end of the exposure to MEK. The blood concentrations of MEK, 2-butanol, and 2,3-butanediol were monitored during and after the exposure. MEK concentrations in exhaled air and MEK and 2,...